Event Details

Date:
Wednesday, 13 July 2016
Time:
12:00 pm - 1:00 pm
Room:
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
URL:
http://www.qbi.uq.edu.au/neuroscience-seminars
Event category(s):

Event Contact

Name:
Ms Deirdre Wilson
Phone:
334 66300
Email:
d.wilson5@uq.edu.au
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Dr Jason Howitt,
Florey Research Fellow and Lab Head, Protein Trafficking and Signalling Laboratory
The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052

Title: Targeting autism using mechanism based therapeutics- Can we cure autism and do we want to?

Abstract: Autism spectrum disorders (ASDs) represent a diverse set of neurodevelopmental conditions affecting approximately 1 in every 100 children. The genetic heterogeneity of ASD presents a significant challenge for understanding the biology of the condition; with so many different ‘causes’, a key question is how can we develop treatments to target ASD?

A promising approach to this complex problem is to study single-gene variants associated directly with the disorder. Mutations in the gene PTEN are known to cause autism with macrocephaly (PTEN-ASD). To investigate pathway alterations occurring in the PTEN-ASD brain we have developed a novel developmental mouse model that has a number of phenotypes parallel to symptoms of PTEN-ASD patients.

By studying the brains of these PTEN-ASD mice we have identified mechanistic pathways that are altered in the developing brain. We demonstrate that a combination of drug treatments that target these perturbed pathways, can rescue the PTEN-ASD brain phenotypes. These findings show the utility of the PTEN-ASD mouse model as a pre-clinical tool for identifying disease modifying therapeutics in autism spectrum disorders.

Directions to UQ

Google Map:
Directions:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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