QBI Neuroscience Seminar: Molecular mechanisms associated with neural network dysfunction in Alzheimer’s disease

Event Details

Date:

Wednesday, 25 May 2016

Time:

12:00 pm - 1:00 pm

Room:

QBI Level 7 Auditorium

UQ Location:

Relaxation Block (St Lucia)

URL:

http://www.qbi.uq.edu.au/neuroscience-seminars

Event category(s):

Full Description:: Professor David Small
Professorial Fellow, Menzies Institute of Medical Research, University of Tasmania

Title: Molecular mechanisms associated with neural network dysfunction in Alzheimer’s disease

Abstract:
The molecular mechanisms which cause Alzheimer’s disease have been intensively studied for many years. The central role of Abeta in the pathogenesis of the disease is now well known. However, the factors which drive disease progression and the mechanisms that control the spatio-temporal pattern of neurodegeneration are still poorly understood. In the talk, I will examine the role of the amyloid precursor protein (APP), not only in the generation of the Abeta protein, but also its normal function in neuronal growth and repair. The idea that APP may contribute actively not only to driving disease progression but also to defining the spatio-temporal pattern of neurodegeneration will be discussed.