Event Details

Thursday, 07 April 2016 - Thursday, 07 April 2016
11:30 am - 12:30 pm
QBI Level 7 Seminar Room
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Deirdre Wilson
3346 6300
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
CiRong Liu, Queensland Brain Institute, University of Queensland

Title: Studying brainnetome of DISC1 and socially isolated mice with diffusion MRI

“Disrupted-In-Schizophrenia-1” (DISC1) plays critical roles in neurodevelopment by regulating neurogenesis, migration, and dendrite/spine density via its interaction with many other proteins. However, the roles of the DISC1 in white matter development and brain networks are unclear, despite the fact that DISC1 is a promising risk gene for many mental illnesses associated with white matter abnormalities and disconnection syndromes. The main purpose of my PhD project is to investigate whether DISC1 functions in the development of the white matter and structural brain networks using DISC1 transgenic mice and neuroimaging techniques. Meanwhile, we also examined the effect of adolescent social isolation (as an environmental stressor) and its putative interaction effect with the DISC1 gene. The project brings new knowledge on the functions of the DISC1 gene and the effect of social deprivation, and shows that diffusion MRI is a powerful whole-brain mapping technique to reveal new endo-phenotypes in animal models of diseases.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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