Event Details

Date:
Wednesday, 10 February 2016 - Wednesday, 10 February 2016
Time:
12:00 pm - 1:00 pm
Room:
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
URL:
http://www.qbi.uq.edu.au/neuroscience-seminars
Event category(s):

Event Contact

Name:
Ms Deirdre Wilson
Phone:
3346 6300
Email:
d.wilson5@uq.edu.au
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
A/Professor Kai-Hsiang Chuang, Queensland Brain Institute, University of Queensland

Title: Restless resting state: neural basis and application in rodent models

Abstract:

Synchronous neural oscillation across the brain provides information on the functional connectivity of the brain. In the past decade, spontaneous low-frequency oscillation of the resting brain shows networks that match functional organization of the brain has been observed, especially using resting-state functional MRI (rsMRI). Functional network plasticity and its deficit in development, mental processes, aging and diseases have been observed. While many studies have tried to correlate rsMRI with electrophysiology and structural connectivity, its underlying neurophysiological and neuroarchitectural bases are still not clear.

To understand the neural basis of rsMRI and to determine whether it can be a translatable biomarker for biomedical research, we established the technique in anesthetized rodent brain. Using drugs that target to specific neural receptors, we observed that functional connectivity strength is regional receptor density, drug dosage and time dependent. Correlation with electrophysiology further confirms the change was not due to vascular response. The technique was applied to measure neural plasticity after learning, and to evaluate treatment effects in transgenic mouse models of neurodegenerative diseases. These understanding will facilitate our interpretation of the rsMRI signals and the translation from animal models to human.

Directions to UQ

Google Map:
Directions:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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