QBI Seminar: Diabetes and the nervous system: the journey from animal models to neuroprotective treatments
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- A/Professor Arun Krishnan,
Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales,
Title: Diabetes and the nervous system: the journey from animal models to neuroprotective treatments
Abstract:
Diabetic complications are highly prevalent worldwide and may affect any level of the nervous system. Recent work has demonstrated evidence of central nervous system dysfunction, presenting as cognitive impairment that may occur in addition to the highly prevalent complication of peripheral neuropathy, which is associated with sensory impairment, neuropathic pain motor complications. Studies in animal models have provided evidence that impulse conduction in diabetic nerves may be impaired due to axo-glial dysjunction and consequent alterations in axonal ion channel function. More recent work in the human setting has demonstrated that glucose variability may play a role in mediating axonal dysfunction in diabetes and that novel methods of insulin delivery may have neuroprotective potential in diabetes. These studies have provided the basis for recent clinical trials that will explore methods of neuroprotection in diabetic patients.
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