CAI Seminar: Caramel, guts and kidneys…A fresh perspective on diabetes
Event Details
- Date:
- Tuesday, 21 October 2014 - Tuesday, 21 October 2014
- Time:
- 9:00 am - 10:00 am
- Room:
- Level 2 Seminar Room, CAI Building 57
- Location:
- CAI building 57 St Lucia
- Event category(s):
Event Contact
- Name:
- Dr Christopher Noble
- Phone:
- 60360
- Email:
- c.noble@uq.edu.au
- Org. Unit:
- Advanced Imaging
Event Description
- Full Description:
- Professor Josephine M Forbes, NHMRC Senior Research Fellow and Professor at the Mater Clinical School, University of Queensland will present a seminar on the connection between advanced glycation end products (AGEs) and diabetes.
Advanced glycation end products (AGEs) are formed in the body when lysine and arginine residues in proteins and peptides become irreversibly modified by reactive sugars or carbonyls. AGEs can also be absorbed from dietary sources, in particular in westernised diets as a result of modern food processing. Cooking methods can alter the AGE content of foodstuffs. Traditionally, AGEs have been investigated as contributors to diabetic complications since their production is facilitated by hyperglycaemia and the generation of reactive oxygen species. This is particularly evident in studies using inhibitors of advanced glycation to improve these disorders. There is also some evidence that AGE concentrations may serve as biomarkers for progressive injury at sites of diabetic complications and within the circulation. Recently, however, there has been a paradigm shift which suggests that AGEs may be modulators of insulin secretion and peripheral insulin sensitivity as well as cellular energetics and as such, may play a crucial role in the development of diabetes per se. This is most likely via ligation with receptors such as the receptor for advanced glycation end products, RAGE but also with another relatively novel AGE receptor, AGE-R1.
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