QBI Neuroscience Seminar: New insights into Alzheimer’s disease: Mitochondrial dynamics and circadian rhythms.
Event Details
- Date:
- Tuesday, 23 September 2014 - Tuesday, 23 September 2014
- Time:
- 12:00 pm - 1:00 pm
- Room:
- Auditorium, level 7
- UQ Location:
- Queensland Brain Institute (St Lucia)
- URL:
- http://www.qbi.uq.edu.au/neuroscience-seminars
- Event category(s):
Event Contact
- Name:
- Mr Reeza Nazer
- Phone:
- 66353
- Email:
- r.nazer@uq.edu.au
- Org. Unit:
- Queensland Brain Institute
Event Description
- Full Description:
- Speaker: Dr Anne Eckert
Molecular & Cognitive Neuroscience, University of Basel
Psychiatric University Clinics Basel, Switzerland
Seminar Title: New insights into Alzheimer’s disease: Mitochondrial dynamics and circadian rhythms.
Abstract: The histopathological characteristics of Alzheimer’s disease (AD) are amyloid-ß (Aß) containing plaques and neurofibrillary tangles as well as neuronal and synaptic loss.
Until today, the underlying mechanisms of the interplay of plaques and tangles remained unresolved. However, more recently, energy deficiency and mitochondrial dysfunction have been recognized as a prominent, early event in AD. The successful development of single, double and recently triple transgenic mouse models facilitated the investigation of pathogenic mechanisms in AD and assisted in an understanding of the effects of tau as well as the interplay of Aß and tau on bio-energetic processes in vivo.
We examined mitochondrial function tau transgenic mice (pR5 bearing the tau mutation P301L) and in a novel triple transgenic mouse model (pR5/APP/PS2) – tripleAD mice – that combines both pathologic features of the disease in brain. Using comparative, quantitative proteomics approach we found a massive deregulation of 24 proteins, of which one-third were mitochondrial proteins mainly related to complexes I and IV.
Remarkably, deregulation of complex I was related to tau, whereas deregulation of complex IV was Aß dependent, both at the protein and activity levels. Moreover, we investigated changes in mitochondrial morphology as well as fusion and fission in tau and Aß cell culture models. Our findings link pathology features with abnormalities in mitochondrial function and dynamics. Moreover, circadian behavioural abnormalities are frequently associated with ageing and AD.
Interestingly, we found that changes in the mitochondrial architecture were regulated by the biological clock in a cellular model of human daily behavior. Aß altered both the mitochondrial dynamics and the circadian clock at different levels (from genes to functions). Thus, we gained new insights into the relationships between mitochondrial dynamics and circadian clock in AD.
Directions to UQ
- Google Map:
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- Directions:
- St Lucia Campus | Gatton campus.
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