Clark Lab

PEPTIDE CHEMICAL BIOLOGY

 
 

The study of endogenous human peptides and proteins and the isolation and characterisation of bioactive peptides from natural sources has generated huge interest in the development of these molecules for the treatment of a broad range of human diseases. The unifying theme of our research program is to create potent and selective drug leads based on naturally occurring peptides for the treatment of human diseases and to develop novel strategies to provide these molecules with the ability to resist the body’s natural degradation pathways so they are able to reach their biological target.

 

Our Research Focus

Examples of bioactive peptides: The iron regulatory peptide hepcidin (above right); Conotoxins as drug leads (top); The antimicrobial peptide LEAP-2 (above).